Fenfluramine Challenge Test in Obsessive-Compulsive Disorder - First Results

Fenfluramine Challenge Test in Obsessive-Compulsive Disorder - First Results

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Obsessive-compulsive disorder is a chronic psychiatric illness, affecting up to 3% of the general population, to the midle of Refrigerant Gas Leak Detector 60-th it was supposed to be untreatable.Antidepressant pharmacotherapy is one of the treatment alternatives today.We compared efficacy and safety of citalopram versus clomipramine (serotoninergic antidepressants) in 6 weeks in double blind therapy of obsessive-compulsive disorder.The second objective was to compare prolactin response to a fenfluramine challenge test before the treatment of patients and after 6 weeks of the treatment.

In a sample of 14 patients we confirmed significant therapeutic response after 3 weeks of pharmacoterapy, better in obsession than in compulsion.We found low level of adverse effects in the first week of therapy - dry mouth, anxiety, nausea, somnolence, tremor, and sexual adverse events.There were no changes in the laboratory, test EEG, and ECG examinations.Fenfluramine challenge test showed statistically significant decrease of prolactine levels 1 hour after administration of fenfluramine.

It was not observed after six RAPID MASS TRIPLE CHOC weeks of the therapy.Statistically significant negative correlation between prolactine plasma levels at the 6-th hour after administration of fenfluramine and obsession item of YBOC Scale was showed after the 3-rd and 6-th week of the therapy.The correlation was not observed for compulsion item YBOC Scale.Side effects observed during and after the challenge test were anxiety and nervousness and gastrointestinal problems, lasted from l hour to 10 hours.

These preliminary result could support the idea, that obsessions and compulsions have not necessary the same biological background.The challenge paradigm appears to be a possible way to clarify the pathogenesis of OCD.Our study will continue.